Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22 in mice
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چکیده
Karine Laude, Hua Cai, Bruno Fink, Nyssa Hoch, David S. Weber, Louise McCann, Georg Kojda, Tohru Fukai, Harald H. H. W. Schmidt, Sergey Dikalov, Santhini Ramasamy, Graciela Gamez, Kathy K. Griendling, and David G. Harrison Division of Cardiology, Emory University, Atlanta, Georgia; and Institut für Pharmakologie und Klinische Pharmakologie, Duesseldorf, and Rudolf-Bucheim Institut für Pharmacology, Justus-Liebig-Universtat, Giessen, Germany
منابع مشابه
Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice.
Protein levels and polymorphisms of p22(phox) have been suggested to modulate vascular NAD(P)H oxidase activity and vascular production of reactive oxygen species (ROS). We sought to determine whether increasing p22(phox) expression would alter vascular ROS production and hemodynamics by targeting p22(phox) expression to smooth muscle in transgenic (Tg) mice. Aortas of Tg(p22smc) mice had incre...
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Weber, David S., Petra Rocic, Adamantios M. Mellis, Karine Laude, Alicia N. Lyle, David G. Harrison, and Kathy K. Griendling. Angiotensin II-induced hypertrophy is potentiated in mice overexpressing p22 in vascular smooth muscle. Am J Physiol Heart Circ Physiol 288: H37–H42, 2005. First published September 2, 2004; doi:10.1152/ajpheart.00638.2004.—Increased reactive oxygen species (ROS) are imp...
متن کاملAngiotensin II-induced hypertrophy is potentiated in mice overexpressing p22phox in vascular smooth muscle.
Increased reactive oxygen species (ROS) are implicated in several vascular pathologies associated with vascular smooth muscle hypertrophy. In the current studies, we utilized transgenic (Tg) mice (Tg(p22smc)) that overexpress the p22(phox) subunit of NAD(P)H oxidase selectively in smooth muscle. These mice have a twofold increase in aortic p22(phox) expression and H(2)O(2) production and thus p...
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Background: Vascular calcification is an important stage in atherosclerosis. During this stage, vascular smooth muscle cells (VSMC) synthesize many osteogenic factors such as osteonectin (encoded by SPARC). Oxidative stress plays a critical role in atherosclerosis progression, and its accumulation in the vascular wall stimulates the development of atherosclerosis and vascular calcification. The...
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Vascular disease states are associated with endothelial dysfunction and increased production of reactive oxygen species (ROS) derived from vascular NADPH oxidases in both vascular smooth muscle cells (VSMCs) and endothelial cells. Recent evidence suggests an important role for VSMC NADPH oxidases in vascular ROS production. However, it is unclear whether increased NADPH oxidase activity in endo...
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تاریخ انتشار 2004